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KMID : 0604220050120030069
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Korean Journal Investigative Dermatology
2005 Volume.12 No. 3 p.69 ~ p.74
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Jeon Soo-Young
Lee Won-Soo
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Abstract
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Various kinds of hair products have been used widely due to the increase of interest of hair styles. The cosmetic procedures such as permanent dyeing are very popular today, but the medical studies related to the meaning and the restoration pattern of hair damage are mainly based on the structural findings.
The purpose of this study was to identify the patterns of hair damage and restoration through electrophoresis and western blot analysis of the hair proteins. The two volunteers who we selected as subjects did not have any specific medical illness and have not performed any special cosmetic procedures that could have caused hair damage during the previous six months. We conducted permanent dyeing on them. The human hair samples were obtained from the occipital scalp that was not affected by the androgen. We performed extraction and concentration of the whole and partial hair protein, then operated electrophoresis and western blot analysis of the hair protein.
The results were as follows: In the western blot analysis of whole hair proteins, there is no specific finding on both of them. It may result from the small amount of partial proteins among the whole hair proteins. In the western blot analysis of partial hair proteins, subject A and B showed positive findings. Especially, positive findings were found on the 14th week of the experiment.
These results showed change of the hair proteins from hair damage, and we found the possibility of prologation of actual hair damage longer than expected ultrastructurally.
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KEYWORD
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Hair protein, Ubiquitin, Chemical hair damage, Permanent dyeing, Western blot analysis
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